Pathogenic role of glial cells in Parkinson's disease
Identifieur interne : 001726 ( Main/Exploration ); précédent : 001725; suivant : 001727Pathogenic role of glial cells in Parkinson's disease
Auteurs : Peter Teismann [États-Unis] ; Kim Tieu [États-Unis] ; Oren Cohen [États-Unis] ; Dong-Kug Choi [États-Unis] ; Du Chu Wu [États-Unis] ; Daniel Marks [États-Unis] ; Miquel Vila [États-Unis] ; Vernice Jackson-Lewis [États-Unis] ; Serge Przedborski [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2003-02.
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Abstract
An erratum for this article appears in the January, 2004 issue of Movement Disorders (Mov Disord 2004;19:119). Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive loss of the dopaminergic neurons in the substantia nigra pars compacta (SNpc). The loss of these neurons is associated with a glial response composed mainly of activated microglial cells and, to a lesser extent, of reactive astrocytes. This glial response may be the source of trophic factors and can protect against reactive oxygen species and glutamate. Alternatively, this glial response can also mediate a variety of deleterious events related to the production of pro‐oxidant reactive species, and pro‐inflammatory prostaglandin and cytokines. We discuss the potential protective and deleterious effects of glial cells in the SNpc of PD and examine how those factors may contribute to the pathogenesis of this disease. © 2002 Movement Disorder Society
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DOI: 10.1002/mds.10332
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Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive loss of the dopaminergic neurons in the substantia nigra pars compacta (SNpc). The loss of these neurons is associated with a glial response composed mainly of activated microglial cells and, to a lesser extent, of reactive astrocytes. This glial response may be the source of trophic factors and can protect against reactive oxygen species and glutamate. Alternatively, this glial response can also mediate a variety of deleterious events related to the production of pro‐oxidant reactive species, and pro‐inflammatory prostaglandin and cytokines. We discuss the potential protective and deleterious effects of glial cells in the SNpc of PD and examine how those factors may contribute to the pathogenesis of this disease. © 2002 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region><settlement><li>New York</li></settlement><orgName><li>Université Columbia</li></orgName></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Teismann, Peter" sort="Teismann, Peter" uniqKey="Teismann P" first="Peter" last="Teismann">Peter Teismann</name></region><name sortKey="Choi, Dong Ug" sort="Choi, Dong Ug" uniqKey="Choi D" first="Dong-Kug" last="Choi">Dong-Kug Choi</name><name sortKey="Cohen, Oren" sort="Cohen, Oren" uniqKey="Cohen O" first="Oren" last="Cohen">Oren Cohen</name><name sortKey="Jackson Ewis, Vernice" sort="Jackson Ewis, Vernice" uniqKey="Jackson Ewis V" first="Vernice" last="Jackson-Lewis">Vernice Jackson-Lewis</name><name sortKey="Marks, Daniel" sort="Marks, Daniel" uniqKey="Marks D" first="Daniel" last="Marks">Daniel Marks</name><name sortKey="Przedborski, Serge" sort="Przedborski, Serge" uniqKey="Przedborski S" first="Serge" last="Przedborski">Serge Przedborski</name><name sortKey="Przedborski, Serge" sort="Przedborski, Serge" uniqKey="Przedborski S" first="Serge" last="Przedborski">Serge Przedborski</name><name sortKey="Tieu, Kim" sort="Tieu, Kim" uniqKey="Tieu K" first="Kim" last="Tieu">Kim Tieu</name><name sortKey="Vila, Miquel" sort="Vila, Miquel" uniqKey="Vila M" first="Miquel" last="Vila">Miquel Vila</name><name sortKey="Wu, Du Chu" sort="Wu, Du Chu" uniqKey="Wu D" first="Du Chu" last="Wu">Du Chu Wu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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